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In micethe ethanolic extract of Bmonnieri was found to increase cerebral levels of GABA 15 minutes after administration19 Furthermorethe purified bacosides A and B showed dose-dependent effects in the same rat modelsas well as in a taste aversion response test20 A saponin fraction of Bmonnieri reduced spontaneous motor activity in ratsand lowered rectal temperatures in mice21 The same extract showed tranquilizing effects in rats but did not block the conditioned avoidance responseIt also protected against audiogenic seizures22 Bacosinea free triterpene isolated from the aerial parts of Bmonnieriwas found to have analgesic effects operating through opioidergic pathways17 The ethanolic extract of Bmonnieri relaxed smooth muscle preparations of guinea pig and rabbit pulmonary arteriesrabbit aortaand guinea pig trachea by a mechanism that was postulated to involve prostacyclins23 The same investigators found spasmolytic effects of the ethanol extract in guinea pig ileum and rabbit jejeunum to be nonspecifically mediated through calcium channels24.

Oral treatment of rats with the extract of Bmonnieri for 24 days facilitated their ability to learn mazes25 More recentlythe extract was found to improve the performance of rats in various behavioral models of learning3.

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